diff --git a/gcc/testsuite/gcc.target/i386/pr112495.c b/gcc/testsuite/gcc.target/i386/pr112495.c
new file mode 100644
index 0000000000000000000000000000000000000000..21afbaa6945db412566881af2178d3ff20c39b00
--- /dev/null
+++ b/gcc/testsuite/gcc.target/i386/pr112495.c
@@ -0,0 +1,12 @@
+/* { dg-do compile } */
+/* { dg-options "-O3" } */
+
+typedef struct { int v; } T1;
+typedef struct { T1 v[32]; } T2;
+
+T1 s;
+T1 f1() { return s; }
+
+void f2(__seg_gs T2 *p, int n) {
+  for (int i = 0; i < n; ++i) p->v[i] = f1();
+}
diff --git a/gcc/tree-data-ref.cc b/gcc/tree-data-ref.cc
index 689aaeed72282bb0da2a17e19fb923a06e8d62fa..3549485d2513fcc79bebf5f8a3a0f6e0a7db982e 100644
--- a/gcc/tree-data-ref.cc
+++ b/gcc/tree-data-ref.cc
@@ -1640,6 +1640,13 @@ runtime_alias_check_p (ddr_p ddr, class loop *loop, bool speed_p)
 				   "runtime alias check not supported for"
 				   " outer loop.\n");
 
+  /* FORNOW: We don't support handling different address spaces.  */
+  if (TYPE_ADDR_SPACE (TREE_TYPE (TREE_TYPE (DR_BASE_ADDRESS (DDR_A (ddr)))))
+      != TYPE_ADDR_SPACE (TREE_TYPE (TREE_TYPE (DR_BASE_ADDRESS (DDR_B (ddr))))))
+    return opt_result::failure_at (DR_STMT (DDR_A (ddr)),
+				   "runtime alias check between different "
+				   "address spaces not supported.\n");
+
   return opt_result::success ();
 }